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Work in recent years has concentrated on the non uniformities of sarcomere lengths during stretch of active muscle at lengths beyond the optimum for tension generation. The popping sarcomere hypothesis postulates that lengthening of muscle under these conditions does not take place by uniform lengthening of sarcomeres, but more nearly by popping, or rapid unstable lengthening, of sarcomeres one at a time in order from the weakest to the strongest. This is the pain and tenderness in muscles typically felt one to two days after unaccustomed exercise involving lengthening of muscle while generating tension, known as eccentric exercise. The mysteries have been why the damage occurs, and what changes with training to reduce the damage. I have suggested that it is the sarcomere non uniformities that initiate the damage, and that training consists of growing extra sarcomeres in order to avoid working at long sarcomere length. Recent work has shown that decline exercised rats to have more sarcomeres in their fibres, and do generate optimum tension at longer muscle length. (Paper in review) Other work has shown extra series compliance after a series of stretches that is predicted by the theory in humans, whole muscles and single fibres, and shown the importance of muscle length in determining the extent of the damage. buy meizitang botanical slimming soft gel Alice also puts three rugby players through their paces to find out how their kidneys cope under the stress of dehydration, and June from Aberdeen in Scotland speaks from her own experience about what happens when kidneys fail. She’s been on dialysis for four years, and her sister, Lorraine, offers her own kidney. But if we’re talking about how much volume the kidneys filter
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